GLP-1 Receptor Agonists
Evidence-based comparison of GLP-1 drugs for weight loss and diabetes management
What Are GLP-1 Drugs?
GLP-1 receptor agonists are a class of medications that mimic glucagon-like peptide-1 (GLP-1), a natural hormone that regulates blood sugar and appetite. These drugs have emerged as some of the most effective treatments available for weight loss and type 2 diabetes management.
How They Work
- Regulate blood sugar: They stimulate insulin release when blood glucose is high, helping maintain stable blood sugar levels
- Reduce appetite: They signal fullness to the brain, helping reduce caloric intake naturally
- Slow digestion: They slow gastric emptying, keeping you satisfied longer
- Protect the heart: Some GLP-1 drugs have been shown to reduce cardiovascular risk in people with diabetes
Clinical Applications
- Type 2 Diabetes: Effective first-line and add-on therapy for blood sugar control
- Weight Loss: FDA-approved for chronic weight management in people with obesity
- Cardiovascular Health: Evidence suggests heart protective benefits beyond weight loss
Semaglutide
8-12% weight loss
Moderate weight loss benefits with well-established safety profile. Available as weekly injections.
View clinical evidence →Tirzepatide
20-24% weight loss
Strongest weight loss results among available GLP-1 drugs. Dual GIP/GLP-1 receptor agonist.
View clinical evidence →Metformin
2-5 lbs weight loss
Minimal weight loss, but foundational therapy for type 2 diabetes and metabolic health.
View clinical evidence →