Quick Answer
Semaglutide carries a black box warning about thyroid C-cell tumors (medullary thyroid carcinoma) based on animal studies. It's contraindicated if you have a history of this cancer or MEN2.
Rare in humans; warning based on animal studies
Why This Happens
In animal models, GLP-1 agonists increased C-cell proliferation. The relevance to humans is debated, but the FDA requires the warning.
If side effects are limiting your progress, a provider can adjust dosing or switch medications based on your response. The right medication match can make all the difference.
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Check Availability →Is It Serious?
Potentially serious. This is why semaglutide is contraindicated in people with personal or family history of medullary thyroid cancer.
When to Contact Your Doctor
- Do not take semaglutide if you have a personal or family history of medullary thyroid cancer.
- Do not take if you have multiple endocrine neoplasia type 2 (MEN2).