Quick Verdict
Semaglutide wins decisively for weight loss. Use together for best metabolic outcomes.
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Check Availability →Side-by-Side Comparison
| Metric | Semaglutide | Metformin |
|---|---|---|
| Weight Loss | 8-12% over 1 year | 2-5 lbs over several months |
| Common Side Effects | Nausea, vomiting, GI issues | GI upset, metallic taste (usually mild) |
| Cost | $900-1200/month | $20-50/month |
Key Tradeoffs
Semaglutide: Dramatically superior weight loss effectiveness
Metformin: Minimal side effects, prevents diabetes, 100x cheaper
Verdict
Best option: Semaglutide
8-12% weight loss vs 2-5 lbs with metformin
Alternative: Semaglutide
25+ year safety record, foundational diabetes therapy