Quick Verdict
Tirzepatide wins for weight loss. Semaglutide wins for tolerability and cost.
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Check Availability →Side-by-Side Comparison
| Metric | Semaglutide | Tirzepatide |
|---|---|---|
| Weight Loss | 8-12% over 1 year | 20-24% over 1 year |
| Common Side Effects | Nausea, vomiting, diarrhea | Similar, potentially more common due to stronger effect |
| Cost | $900-1200/month | $1200-1500/month |
Key Tradeoffs
Semaglutide: Lower cost, well-established safety, proven track record since 2017
Tirzepatide: Nearly 2x stronger weight loss, ideal for severe obesity
Verdict
Best option: Tirzepatide
20-24% weight loss (nearly 2x semaglutide)
Alternative: Semaglutide
Lower cost, better tolerability